Marine Functional Metabolites

Functional metabolites are biological molecules that have key physiological and behavioural functions that ensure the fitness and survival of an organism but that are not involved in primary metabolism such as proteins and nucleic acids that make up the basic machinery of life. The term functional metabolite is new and used as an alternative to the more often-used term “secondary metabolite” that considers these compounds as causing long-term impairment but not immediate death of an organism, or as causing no effect at all. The difference with our definition is that these compounds are not secondary but always serve a function that is necessary for the well-being and survival of an organism. The term functional metabolite differs from “natural product” which generally intends compounds with biomedical potential leading to drug discovery, but is rarely used in the ecological context. Other often-used terms with a more ecological context are “infochemicals” or “semiochemicals” that are defined as compounds that convey information between individuals thereby evoking a physiological or behavioral response in the receiver. Whatever term used, metabolites of this nature generally represent only a tiny fraction of the total biomass of an organism compared to primary metabolites, and it is not always clear what the function of these compounds is and what advantages they offer to the producing organism. To date, more than 18,000 of these metabolites have been described from sponges, ascidians, soft corals, seaweeds, marine microbes and many other benthic and pelagic organisms, with more being discovered daily. Many of these compounds play fundamental roles as defences against predators, competitors and pathogens, and for the selection of mates and habitats. Without these compounds many key physiological processes would cease to exist, with catastrophic consequences on ecosystem functionality.

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